5c–d). CX-5461-mediated S33 phosphorylation of RPA was impartial with the cell cycle stage and wasn't restricted on the nucleoli in HR-deficient cells. Therefore, the development of ssDNA constructions in CX-5461 addressed cells may lead to replication fork stalling and ATR activation with HRD exacerbating CX-5461-mediated replication tension w
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Quite a few research have indicated that compounds that directly or indirectly target ULK1 can be used for tumor therapy. Even so, stories from the therapeutic results of those compounds have come to conflicting conclusions. On this do the job, we reviewed the latest experiments relevant to the results of ULK1 on the regulation of autophagy and the